On 4th October 2013, the new headquarters was inaugurated in Palazzo Peruzzi de’ Medici (otherwise known as Palazzo Pannocchieschi D’Elci) in via Maggio 28-28A, which is situated opposite the previous location. Palazzo Peruzzi de’ Medici was restored in the seventeenth century by Gherardo Silvani, one of the most important architects and sculptors, active that century in Florence.

In 2001, Pananti had moved from their historic site in Piazza Santa Croce to Via Maggio 15, in Palazzo di Cosimo Ridolfi, which remained their premises until 2013.